Y. Pei, T. Tuschl,
On the art of identifying effective and specific siRNAs, Nature Methods, 2006, in press.

A. Aravin, D. Gaidatzis, S. Pfeffer, M. Lagos-Quintana, P. Landgraf, N. Iovino, P. Morris, M. J. Brownstein, S. Kuramochi-Miyagawa, T. Nakano, M. Chien, J. J. Russo, J. Ju, R. Sheridan, C. Sander, M. Zavolan, T. Tuschl,
A novel class of small RNAs bind to MILI protein in mouse testes, Nature, 2006, 442, 203-207.

M. Hossbach, J. Gruber, M. Osborn, K. Weber, T. Tuschl,
Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs, RNA Biol., 2006, 3, 1-8.

A. Sewer, N. Paul, P. Landgraf, A. Aravin, S. Pfeffer, M. J. Brownstein, T. Tuschl, E. van Nimwegen, M. Zavolan,
Identification of clustered microRNAs using an ab initio prediction method, BMC Bioinformatics, 2005, 6, 267.

G. Meister, M. Landthaler, L. Peters, J. Chen, H. Urlaub, R. LŸhrmann, T. Tuschl,
Identification of novel Argonaute-associated proteins, Curr. Biol. 2005, 15, 2149-2155.

J. KrŸtzfeldt, N. Rajewsky, R. Braich, K. G. Rajeev, T. Tuschl, M. Manoharan, M. Stoffel,
Silencing of microRNAs in vivo with ÔantagomirsÕ, Nature 2005, 438, 685-689.

A. Aravin, T. Tuschl,
Identification and characterization of small RNAs involved in RNA silencing, FEBS Lett. 2005, 579, 5830-5840.

Y.-R. Yuan, Y. Pei, J.-B. Ma, V. Kuryavyi, M. Zhadina, G. Meister, H.-Y. Chen, Z. Dauter, T. Tuschl, D. J. Patel,
Crystal structure of A. aeolicus Argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage, Mol. Cell, 2005, 19, 405-419.

J. Gruber, H. Manninga, T. Tuschl, M. Osborn, K. Weber,
Specific RNAi mediated gene knockdown in zebrafish cell lines, RNA Biol., 2005, 2, 101-105.

S. Pfeffer, G. Meister, M. Landthaler, T. Tuschl,
RNA Silencing: 90th International Titisee Conference, B. I. F. Futura, 2005, 20, 83-91. (download as PDF, 252 kb)

D. Leaman, P. Y. Chen, J. Fak, A. Yalcin, M. Pearce, U. Unnerstall, D. S. Marks, C. Sander, T. Tuschl, U. Gaul,
Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development, Cell, 2005, 121, 1097-1108.

P. Y. Chen, H. Manninga, S. K., M. Chien, J. J. Russo, J. Ju, R. Sheridan, B. John, D. S. Marks, D. Gaidatzis, C. Sander, M. Zavolan, T. Tuschl,
The developmental miRNA profiles of zebrafish as determined by small RNA cloning, Genes & Dev., 2005, 19, 1288-1293.

Y. Altuvia, P. Landgraf, G. Lithwick, N. Elefant, S. Pfeffer, A. Aravin, M. J. Brownstein, T. Tuschl, H. Margalit,
Clustering and conservation patterns of human microRNAs, Nucleic Acids Res., 2005, 33, 2697-2706.

J. B. Ma, Y. R. Yuan, G. Meister, Y. Pei, T. Tuschl, D. J. Patel,
Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein, Nature, 2005, 434, 666-670.

S. Pfeffer, A. Sewer, M. Lagos-Quintana, R. Sheridan, C. Sander, M. Zavolan, F. A. Grässer, L. F. van Dyk, C. K. Ho, S. Shuman, M. Chien, J. J. Russo, J. Ju, G. Randall, B. D. Lindenbach, C. M. Rice, V. Simon, D. D. Ho, M. Zavolan, T. Tuschl,
Identification of microRNAs of the herpesvirus family, Nature Meth., 2005, 2, 269-276.

C. Paludan, D. Schmid, M. Landthaler, M. Vockerodt, D. Kube, T. Tuschl, C. Münz,
Endogenous MHC class II processing of a viral nuclear antigen after autophagy, Science, 2005, 307, 593-596.

M. Landthaler, A. Yalcin, T. Tuschl,
The human DiGeorge Syndrome Critical Region Gene 8 and its D. melanogaster homolog are required for miRNA biogenesis, Curr. Biol, 2004, 14, 2162-2167.

M. N. Poy, L. Eliasson, J. Krutzfeldt, S. Kuwajima, X. Ma, P. E. MacDonald, S. Pfeffer, T. Tuschl, N. Rajewsky, P. Rorsman, M. Stoffel,
A pancreatic islet-specific microRNA regulates insulin secretion, Nature, 2004, 432, 226-230.

B. John, A. J. Enright, A. Aravin, T. Tuschl, C. Sander, D. S. Marks,
Human microRNA targets, PLoS, 2004, 2, e363.

G. Meister, T. Tuschl,
Mechanisms of gene silencing by double-stranded RNA, Nature, 2004, 431, 343-349.

G. Meister, M. Landthaler, A. Patkaniowska, Y. Dorsett, G. Teng, T. Tuschl,
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs, Mol. Cell, 2004, 15, 185-197.

J. Gruber, G. Boese, T. Tuschl, M. Osborn, K. Weber,
RNA interference by osmotic lysis of pinosomes: liposome-independent transfection of siRNAs into mammalian cells, BioTechniques, 2004, 37, 96-102.

B. Yuan, R. Latek, M. Hossbach, T. Tuschl, F. Lewitter,
siRNA Selection Server: an automated siRNA oligonucleotide prediction server, Nucleic Acids Res., 2004, 32, W130-134.

C. L. Will, C. Schneider, M. Hossbach, H. Urlaub, R. Rauhut, S. Elbashir, T. Tuschl, R. Lührmann,
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome, RNA, 2004, 10, 929-941.

S. Pfeffer, M. Zavolan, F. A. Grasser, M. Chien, J. J. Russo, J. Ju, B. John, A. J. Enright, D. Marks, C. Sander, T. Tuschl,
Identification of virus-encoded microRNAs, Science, 2004, 304, 734-736.

J. Martinez, T. Tuschl,
RISC is a 5' phosphomonoester-producing RNA endonuclease, Genes Dev., 2004, 18, 975-980.

Y. Dorsett, T. Tuschl,
siRNAs: applications in functional genomics and potential as therapeutics, Nat. Rev. Drug Discov., 2004, 3, 318-329.

G. Meister, M. Landthaler, Y. Dorsett, T. Tuschl,
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing, RNA, 2004, 10, 544-550.

A. Patkaniowska, T. Tuschl,
Gene silencing by synthetic siRNA duplexes in mammalian cell culture: in RNA interference (RNAi), Nuts and bolts of RNAi technology, D. R. Engelke (ed.), DNA Press, 2003, 71-88.

A. J. Enright, B. John, U. Gaul, T. Tuschl, C. Sander, D. S. Marks,
MicroRNA targets in Drosophila, Genome Biol., 2003, 5(1):R1.

S. Pfeffer, M. Lagos-Quintana, T. Tuschl,
Cloning of small RNA molecules, Curr. Prot. Mol. Biol, 2003, 26.4.1-26.4.18.

A. Aravin, M. Lagos-Quintana, A. Yalcin, M. Zavolan, D. Marks, B. Snyder, T. Gaasterland, J. Meyer, T. Tuschl,
The small RNA profile during Drosophila melanogaster development, Dev. Cell, 2003, 5, 337-350.

J. Harborth, S. M. Elbashir, K. Vandenburgh, H. Manninga, S. A. Scaringe, K. Weber, T. Tuschl,
Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing, Antisense Nucleic Acid Drug Dev., 2003, 13. 83-106.

T. Tuschl,
Functional genomics: RNA sets the standard, Nature, 2003, 421, 220-221.

V. Ambros, B. Bartel, D. P. Bartel, C. B. Burge, J. C. Carrington, X. Chen, G. Dreyfuss, S. R. Eddy, S. Griffiths-Jones, M. Marshall, M. Matzke, G. Ruvkun, T. Tuschl,
A uniform system for microRNA annotation, RNA, 2003, 9, 277-279.

M. Lagos-Quintana, R. Rauhut, J. Meyer, A. Borkhardt, T. Tuschl,
New microRNAs from mouse and human, RNA, 2003, 9, 175-179.

T. Tuschl,
Mammalian RNA interference: in RNAi, a guide to gene silencing, G. J. Hannon (ed.), Cold Spring Harbor Laborotory Press, Cold Spring Harbor, NY, 2003, 265-295.

T. Tuschl, A. Borkhardt,
Small interfering RNAs: A revolutionary tool for the analysis of gene function and gene therapy, Molecular Interventions, 2002, 2, 158-167. (download as PDF, 212 kb)

T. Tuschl,
Expanding small RNA interference, Nat. Biotechnol., 2002, 20, 446-448.

J. Martinez, A. Patkaniowska, H. Urlaub, R. Lührmann, T. Tuschl,
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi, Cell, 2002, 110, 563-574.

M. Lagos-Quintana, R. Rauhut, A. Yalcin, J. Meyer, W. Lendeckel, T. Tuschl,
Identification of tissue-specific microRNAs from mouse, Current Biology, 2002, 12, 735-739.

S. M. Elbashir, J. Harborth, Klaus Weber, T. Tuschl,
Analysis of gene function in somatic mammalian cells using small interfering RNAs, Methods, 2002, 26, 199-213. (download as PDF, 776 kb)

J. Harborth, S. M. Elbashir, K. Bechert, T. Tuschl, Klaus Weber,
Identification of essential genes in cultured mammalian cells using small interfering RNAs, J. Cell Sci., 2001, 114, 4557-4565.

S. M. Elbashir, J. Martinez, A. Patkaniowska, W. Lendeckel, T. Tuschl,
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate, EMBO J., 2001, 20, 6877-6888.

M. Lagos-Quintana, R. Rauhut, W. Lendeckel, T. Tuschl,
Identification of novel genes coding for small expressed RNAs, Science, 2001, 294, 853-858.

G. Hutvagner, J. McLachlan, E. Balint, T. Tuschl, P. D. Zamore,
A cellular function for the RNA interference enzyme Dicer in small temporal RNA maturation, Science, 2001, 293, 834-838.

S. M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, Klaus Weber, T. Tuschl,
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells, Nature, 2001, 411, 494-498.

T. Tuschl,
RNA interference and small interfering RNAs, ChemBioChem, 2001, 2, 239-245. (download as PDF, 120 kb)

S. M. Elbashir, W. Lendeckel, T. Tuschl,
RNA interference is mediated by 21 and 22 nt RNAs, Genes Dev., 2001, 15, 188-200.

T. Tuschl, P. A. Sharp, D. P. Bartel,
A ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formation, RNA, 2001, 7, 29-43.

P. D. Zamore, T. Tuschl, P. A. Sharp, D. P. Bartel,
RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals, Cell, 2000, 101, 25-33.

T. Tuschl, P. D. Zamore, R. Lehmann, D. P. Bartel, P. A. Sharp,
Targeted mRNA degradation by double-stranded RNA in vitro, Genes Dev., 1999, 13, 3191-3197.

C. B. Burge, T. Tuschl, P. A. Sharp,
Splicing of precursors to mRNAs by the spliceosomes: in The RNA World 2nd edition, R. F. Gesteland, T. R. Cech, J. F. Atkins (eds.), Cold Spring Harbor Laborotory Press, Cold Spring Harbor, NY, 1999, 525-560.

T. Tuschl, P. A. Sharp, D. P. Bartel,
Selection in vitro of novel ribozymes from a partially randomized U2 and U6 snRNA library, EMBO J., 1998, 17, 2637-2650.

M. Menger, T. Tuschl, F. Eckstein, D. Porschke,
Mg2+-Dependent conformational changes in the hammerhead ribozyme, Biochemistry, 1996, 35, 14710-14716.

J. B. Thomson, T. Tuschl, F. Eckstein,
The hammerhead ribozyme: in Nucleic Acids in Molecular Biology, F. Eckstein, D. M. J. Lilley (eds.), Springer Verlag, Berlin, Germany, 1996, Vol. 10, 173-196.

S. T. Sigurdsson, T. Tuschl, F. Eckstein,
Probing RNA tertiary structure: Interhelical cross-linking of hammerhead ribozyme, RNA, 1995, 1, 575-583.

T. Tuschl, J. B. Thomson, F. Eckstein,
Catalysis by small RNAs, Curr. Opin. Struct. Biol., 1995, 5, 296-302.

F. Eckstein, O. Heidenreich, M. M. P. Ng, T. Tuschl,
Oligonucleotides: in Molecular Biology and Biotechnology, Robert A. Meyers (ed.), VCH Publisher, New York, USA, 1995, 621-625.

T. Tuschl, C. Gohlke, T. M. Jovin, E. Westhof, F. Eckstein,
A three-dimensional model for the hammerhead ribozyme based on fluorescence measurements, Science, 1994, 266, 785-789.

M. M. P. Ng, F. Benseler, T. Tuschl, F. Eckstein,
Isoguanosine substitution of conserved adenosines in the hammerhead ribozyme, Biochemistry, 1994, 33, 12119-12126.

H. Aurup, T. Tuschl, F. Benseler, J. Ludwig, F. Eckstein,
Oligonucleotide duplexes containing 2'-amino-2'-deoxycytidines: Thermal stability and chemical reactivity, Nucleic Acids Res., 1994, 22, 20-24.

J. B. Thomson, T. Tuschl, F. Eckstein,
Activity of hammerhead ribozymes containing non-nucleotidic linkers, Nucleic Acids Res., 1993, 21, 5600-5603.

T. Tuschl, M. M. P. Ng, W. Pieken, F. Benseler, F. Eckstein,
Importance of exocyclic base functional groups of central core guanosines for Hammerhead Ribozyme Activity, Biochemistry, 1993, 32, 11658-11668.

T. Tuschl, F. Eckstein,
Hammerhead ribozymes: Importance of stem-loop II for activity, Proc. Natl. Acad. Sci. USA, 1993, 90, 6991-6994.

J. L. Luche, C. Einhorn, J. Einhorn, J. C. de Souza Barboza, C. Petrier, C. Dupuy, P. Delair, C. Allavena, T. Tuschl,
Ultrasonic waves as promoters of radical processes in chemistry: The case of organometallic reactions, Ultrasonics, 1990, 28, 316-321.