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Research in the Shaham Lab
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Apoptosis (programmed cell death) is essential for metazoan development.
We study apoptosis in the nematode C. elegans, and are interested
in understanding cues that regulate apoptosis during development. To
this end we have used genetic strategies to identify cell-specific
apoptosis regulators. The remarkable conservation of the apoptotic
machinery suggests that our studies will yield insight into the
regulation of mammalian apoptosis.
Glia account for 90 percent of the cells in the human brain, yet compared to their neuronal counterparts little is known about their development, function and morphogenesis. C. elegans contains 24 neuron-associated cells that are strikingly similar to vertebrate glia. We are interested in understanding how these cells develop, acquire their morphologies and regulate neuronal activity. We are using laser ablation, time-lapse microscopy, genomic and genetic approaches to address these issues. |
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Research: Apoptosis
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Cells overexpressing the BH3-domain protein CED-13 undergo apoptosis in a C. elegans embryo.
 Research: Glia )
Glial-like cell (green) associates with two neuronal processes (red) in the
C. elegans phasmid sensillum.
NCBI Query: WormBase Query: |