The Sakmar lab's research program focuses on the molecular mechanism
of transmembrane signal transduction by a ubiquitous family of
cell-surface receptors called G protein-coupled receptors (GPCRs).
GPCRs are specialized proteins woven into the membranes of cells by
seven transmembrane segments. They transport signals from outside a
cell to the interior, where they can elicit a response on cellular
physiology, growth, development, or differentiation. GPCRs are thus
key to regulating a wide range of cellular signaling pathways.
Signaling pathways under study in our laboratory include those involved
in visual perception,
glucose metabolism,
HIV entry into cells, and
synaptic signaling.
Recent collaborations
Research support
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