Selected Publications

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Reviews

W. An and R.G. Roeder. Reconstitution and transcriptional analysis of chromatin in vitro. Methods Enzymol.Vol. 377:460-474, 2004

R.G. Roeder. Lasker Basic Medical Research Award, The eukaryotic transcriptional machinery: complexities and mechanisms unforeseen. Nature Medicine 9: 1239-1244, 2003

S. Malik and R.G. Roeder. Isolation and functional characterization of the TRAP/Mediator complex. Methods Enzymol. Vol.364:257-284, 2003

S. Malik and R.G. Roeder. Regulation of basal transcription by RNA polymerase II. Handbook of Cell Signaling Vol. 3, Chapter 271, 2003

M. Ito and R.G. Roeder. The TRAP/SMCC/Mediator complex and thyroid hormone receptor function. Trends Endocrin. Met. 12: 127-134, 2001.

S. Malik and R.G. Roeder. Transcriptional regulation through mediator-like complexes in yeast and metazoan cells. Trends Biochem. Sci. 25: 277-283, 2000.

Y. Luo and R.G. Roeder. B cell-specific coactivator OCA-B: Biochemical aspects, role in B cell development and beyond. Cold Spr. Harb. Symp. Quant. Biol. Vol. LXIV: 119-131, 1999.

R.G. Roeder. The role of general and gene-specific cofactors in the regulation of eukaryotic transcription. Cold Spr. Harb. Symp. Quant. Biol. Vol. LXIII: 201-218, 1998.

R.G. Roeder. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem. Sci. 21: 327-335, 1996.

General Initiation Factors and Mechanisms for Transcription by RNA Polymerase II

K. Kamada, R.G. Roeder and S.K. Burley. Molecular mechanism of recruitment of TFIIF- associating CTD phosphatase (FCP1) phosphatase recruitment by transcription factor IIF. Proc. Natl. Acad. Sci. USA 100: 2296-2299, 2003.

K. Leach, K. Vieira, S.-H. Kang, A. Aslanian, M. Teichmann, R.G. Roeder and J. Bungert. Characterization of human β-globin downstream promoter elements. Nucleic Acids Res. 31: 1292-1301, 2003.

H.J. Baek, S. Malik, J. Qin and R.G. Roeder. Requirement of TRAP/Mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF_IIs. Mol. Cell. Biol. 22: 2842-2852, 2002.

C.S. Brower, S. Sato, C. Tomomori-Sato, T. Kamura, A. Pause, R. Stearman, R.D. Klausner, S. Malik, W.S. Lane, I. Sorokina, R.G. Roeder, J.W. Conaway and R.C. Conaway. Mammalian mediator subunit mMED8 is an elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc. Natl. Acad. Sci. USA 99: 10353-10358, 2002.

M. Guermah, Y. Tao and R.G. Roeder. Positive and negative TAF_II functions that suggest a dynamic TFIID structure and elicit synergy with TRAPs in activator-induced transcription. Mol. Cell. Biol. 21: 6882-6894, 2001.

K. Kamada, F. Shu, H. Chen, S. Malik, G. Stelzer, R.G. Roeder, M. Meisterernst and S.K. Burley. Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. Cell 106: 71-81, 2001.

Transcriptional Activation by Nuclear Receptors in Homeostasis and Cell Differentiation

S. Wang, K. Ge, R.G. Roeder and O. Hankinson. Role of mediator in transcriptional activation by the aryl hydrocarbon receptor. J. Biol. Chem. 279:13593-13600, 2004

A.E. Wallberg, S. Yamamura, S. Malik, B.M. Spiegelman and R.G. Roeder. Coordination of p300-mediated chromatin remodeling and TRAP/Mediator function through coactivator PGC-1α. Mol. Cell 12: 1137-1149, 2003

K. Hosohata, P. Li, Y. Hosohata, J. Qin, R.G. Roeder and Z. Wang. Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. Mol. Cell. Biol. 23: 7019-7029, 2003.

Y.-H. Goo, Y.C. Sohn, D.-H. Kim, S.-W. Kim, M.-J. Kang, D.-J. Jung, E. Kwak, N.A. Barlev, S.L. Berger, V.T. Chow, R.G. Roeder, D.O. Azorsa, P.S. Meltzer, P.-G. Suh, E.J. Song, K.-J. Lee, Y.C. Lee and J.W. Lee. Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol. Cell. Biol. 23: 140-149, 2003.

P. Li, X. Yu, K. Ge, J. Melamed, R.G. Roeder and Z. Wang. Heterogeneous expression and functions of androgen receptor co-factors in primary prostate cancer. Am. J. Pathol. 161: 1467-1474, 2002.

E. Mueller, S. Drori, A. Aiyer, J. Yie, P. Sarraf, H. Chen, S. Hauser, E.D. Rosen, K. Ge, R.G. Roeder and B.M. Spiegelman. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor γisoforms. J. Biol. Chem. 277: 41925-41930, 2002.

S. Malik, A.E. Wallberg, Y.K. Kang and R.G. Roeder. TRAP/SMCC/Mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol. Cell. Biol. 22: 5626-5637, 2002.

K. Ge, M. Guermah, C.-X. Yuan, M. Ito, A.E. Wallberg, B.M. Spiegelman and R.G. Roeder. Transcription coactivator TRAP220 is required for PPARγ2-stimulated adipogenesis. Nature 417: 563-567, 2002.

Y.K. Kang, M. Guermah, C.-X. Yuan and R.G. Roeder. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Proc. Natl. Acad. Sci. USA 99: 2642-2647, 2002.

X. Yu, P. Li, R.G. Roeder and Z. Wang. Inhibition of androgen receptor-mediated transcription by the amino-terminal enhancer of split. Mol. Cell. Biol. 21: 4614-4625, 2001.

M. Ito, C.-X. Yuan, H.J. Okano, R.B. Darnell and R.G. Roeder. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol. Cell 5: 683-693, 2000.

M. Ito, C.-X. Yuan, S. Malik, W. Gu, J.D. Fondell, S. Yamamura, Z.-Y. Fu, X. Zhang, J. Qin and R.G. Roeder. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol. Cell 3: 361-370, 1999.

J.D. Fondell, M. Guermah, S. Malik and R.G. Roeder. Thyroid receptor-associated proteins and general positive cofactors mediate thyroid receptor function in the absence of the TATA box-binding protein-associated factors of TFIID. Proc. Natl. Acad. Sci. USA 96: 1959-1964, 1999.

C.-X. Yuan, M. Ito, J.D. Fondell, Z.-Y. Fu and R.G. Roeder. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc. Natl. Acad. Sci. USA 95: 7939-7944, 1998.

J.D. Fondell, H. Ge and R.G. Roeder. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc. Natl. Acad. Sci. USA 93: 8329-8333, 1996.

Transcriptional Regulation During Cell Growth, Proliferation and Differentiation

J. Zhang, M. Kalkum, S. Yamamura, B.T. Chait and R.G. Roeder. E protein silencing by the leukemogenic AML1-ETO fusion protein. Science 305:1286-1289, 2004

W. An, J. Kim and R.G. Roeder. Cooperative ordered functions of p300, PRMT1 and CARM1 in transcriptional activation by p53. Cell Vol. 117:735-748, 2004

J. Luo, M. Li, M. Laszkowska, R.G. Roeder and W. Gu. Acetylation of p53 augments its site specific DNA binding both in vitro and in vivo. Proc. Natl. Acad. Sci. USA 101:2259-2264, 2004

C. Jiang, M. Ito, K.-U. Wagner, K.-R. Park, K. Krumm, J. Pecha, R.G. Roeder and H. Xiao. TIP30 interacts with an ER α-interacting coactivator CIA and regulates c-myc transcription and mammogenesis. J Biol. Chem. 279:27781-27789, 2004.

M. Ito, C. Jiang, K. Krumm, X. Zhang, J. Pecha, J. Zhao, Y. Guo, R.G. Roeder and H. Xiao. TIP30 deficiency increases susceptibility to tumorigenesis. Cancer Res. 63: 8763-8767, 2003

M. Guermah, K. Ge, C.-M.Chiang, and R.G. Roeder. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAF_II implicated in adipogenesis. Mol. Cell 12: 991-1001, 2003

L. Zheng, R.G. Roeder and Y Luo. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell 114: 255-266, 2003.

W. Gu, S. Malik, M. Ito, C.-X. Yuan, J. D. Fondell, X. Zhang, E. Martinez, J. Qin and R.G. Roeder. A novel human SRB/MED-containing cofactor complex (SMCC) involved in transcription regulation. Mol. Cell 3: 97-108, 1999.

W. Gu and R.G. Roeder. Activation of p53 sequence-specific DNA binding by acetylation of its C-terminal domain. Cell 90: 595-606, 1997.

W. Gu, X.-L. Shi and R.G. Roeder. Synergistic activation of transcription by CBP and p53. Nature 387: 819-823, 1997.

Transcriptional Regulation During B-Cell Differentiation and Immune Responses

U. Kim, R. Siegel, X. Ren, C.S. Gunther, T. Gaasterland and R.G. Roeder. Identification of transcription coactivator OCA-B-dependent genes involved in antigen-dependent B cell differentiation by cDNA array analyses. Proc. Natl. Acad. Sci. USA 100: 8868-8873, 2003.

R. Casellas, M. Jankovic, G. Meyer, A. Gazumyan, Y. Luo, R.G. Roeder and M.C. Nussenzweig. OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin κ genes. Cell 110: 575-585, 2002.

X.Yu, L.Wang, Y.Luo and R.G. Roeder. Identification and characterization of a novel OCA-B Isoform: Implications for a role in B cell signaling pathways. Immunity 14: 157-167, 2001.

S. Stevens, J. Ong, U. Kim, L.A. Eckhardt, and R.G. Roeder. Role of OCA-B in 3' IgH enhancer function. J. Immunol. 164: 5306-5312, 2000.

S. Stevens, L. Wang, and R.G. Roeder. Functional analysis of the OCA-B promoter. J. Immunol. 164: 6372-6379, 2000.

U. Kim, C. Gunther and R.G. Roeder. Genetic Analyses of NFKB1 and OCA-B Function: Defects in B-1 and B-2 cells, IgM level, and antibody responses in Nfkb1^-/^- Oca^-b^-/^- mice. J. Immunol. 165:6825-6832, 2000.

X.-F. Qin, A. Reichlin, Y. Luo, R.G. Roeder and M.C. Nussenzweig. OCA-B is required to integrate B-cell antigen receptor, CD40L, and cytokine-mediated signals for humoral immune responses in vivo. EMBO J. 17: 5066-5075, 1998.

Y. Luo, S. Stevens, H. Xiao, H. Ge and R.G. Roeder. Coactivation by OCA-B: definition of critical regions and synergism with general cofactors. Mol. Cell. Biol. 7: 3803-3810, 1998.

U. Kim, X.-F. Qin, S. Gong, S. Stevens, Y. Luo, M. Nussenzweig and R.G. Roeder. The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature 383: 542-547, 1996.

Y. Luo and R.G. Roeder. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol. Cell. Biol. 15: 4115-4124, 1995.

Transcriptional Activation via Chromatin Structural Modifications

W. An, J. Kim and R.G. Roeder. Cooperative ordered functions of p300, PRMT1 and CARM1 in transcriptional activation by p53. Cell Vol. 117:735-748, 2004

P.R. Thompson, D. Wang, L. Wang, M. Fulco, N. Pediconi, D. Zhang, W. An, Q. Ge, R.G. Roeder, J. Wong, M. Levrero, V. Sartorelli, R.J. Cotter, P.A. Cole. Regulation of the p300 HAT Domain via a Novel Activation Loop. Nature Struct. Biol. 11:308-315, 2004.

H. Wang, W. An, R. Cao, L. Xia, H. Erdjument-Bromage, B. Chatton, P. Tempst, R.G. Roeder and Y. Zhang. mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol. Cell 12: 1-20, 2003.

N. Zakharova, E.S. Lymar, E. Yang, S. Malik, J.J. Zhang, R.G. Roeder, and J.E. Darnell, Jr. Distinct transcriptional activation functions of STAT1α and β on DNA and chromatin templates. J.Biol.Chem. 278: 43067-43073, 2003

W. An and R.G. Roeder. Direct association of p300 with unmodified H3 and H4 N-terminal modulates p300-dependent acetylation and transcription of nucleosomal templates. J. Biol. Chem. 278: 1504-1510, 2003.

A.E. Wallberg, K. Pedersen, U. Lendahl and R.G. Roeder. p300 and PCAF can act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol. Cell. Biol. 22: 7812-7819, 2002.

J. Zhang, M. Kalkum, B.T. Chait and R.G. Roeder. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol. Cell 9: 611-623, 2002.

W. An, V.B. Palhan, M.A. Karymov, S.H. Leuba and R.G. Roeder. Selective requirements for histone H3 and H4 N termini in p300-dependent transcriptional activation from chromatin. Mol. Cell 9: 811-821, 2002.

E. Martinez, V. Palhan, A. Tjernberg, E. Lymar, A. Gamper, T. Kundu, B. Chait and R.G. Roeder. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol. Cell. Biol. 21: 6782-6795, 2001.

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