Brain Cell Migration Movies from the Hatten Lab at Rockefeller University
Astrotactin Effect on Cell Migration
Fishell and Hatten, 1991. (Development)
Astrotactin Provides a Neuronal Ligand for Movement along the Glial Fiber. To provide an assay for cell surface receptor systems
that function in neuronal migration, low power views are used to track the movement of a large population of cerebelar granule cells.
In the first sequence, neurons are seen migrating along glial fibers. The application of antibodies against the neuronal protein
astrotactin (flash across the top of the screen) results in rapid arrest of neuronal movement. As migration ceases, the long glial processes
"sway" across the field.
Cell Migration Movies Contents Page
