Brain Cell Migration Movies from the Hatten Lab at Rockefeller University
Single Cell Migration
Gasser and Hatten, 1989. (Proc. Natl. Acad. Sci USA)
Migration of neurons from one brain region along astroglial fibers from another. Immature granule neurons, purified from
the early postnatal cerebellar cortex, migrate along the processes of glial cells isolated from hippocampus. The dynamics of
movement of neurons from one region closely parallel those of neurons from other regions, suggesting that the mode of
migration along glial fibers is stereotyped. The movement of the neuron is saltatory. The leading process extends along
the glial fiber, after which the cell soma appears to contract and then extend just prior to release of the adhesion junction
underneath the cell soma. This sequence is repeated, as the neuron progresses along the glial fiber.
Cell Migration Movies Contents Page
