Rockefeller University

The Rockefeller University
1230 York Avenue
New York, NY 10021

Laboratory of Cardiac/Membrane Physiology

D.W. Bronk Building, Room 307
Tel: (212)327-8617 Fax: (212)327-7589

 

Publications


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Author(s) Year Title Journal Pdf
P. Artigas and D.C. Gadsby 2004 Large diameter of palytoxin-induced Na+/K+-pump channels and modulation of palytoxin interaction by Na+/K+-pump ligands. J. Gen. Physiol. 123(4):357-76. pdf
C. Basso, P. Vergani, A.C. Nairn, D.C. Gadsby 2003 Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating. J. Gen. Physiol. 122(3):333-48. pdf
P. Artigas and D.C. Gadsby 2003 Ion occlusion/deocclusion partial reactions in individual palytoxin-modified Na+ /K+-pump. Ann. N.Y. Acad. Sci.986:116-26. pdf
P. Artigas and D.C. Gadsby 2003 Na+/K+-pump ligands modulate gating of palytoxin- induced ion channels. Proc Natl Acad Sci USA.100:501-505 pdf
P. Vergani, A.C. Nairn and D.C. Gadsby 2003On the Mechanism of MgATP-dependent Gating of CFTR Cl- Channels. J. Gen. Physiol.121(1):17-36 pdf
P. Artigas and D.C. Gadsby 2002 Ion Channel-like Properties Na+/K+ of the Pump. Ann. N.Y. Acad. Sci.976:31-40 pdf
A.G. Dousmanis, A.C. Nairn and D.C. Gadsby 2002 Distinct Mg2+-dependent steps rate limit opening and closing of a single CFTR Cl-channel. J. Gen. Physiol.119:545-59. pdf
R.F. Rakowski, D.C. Gadsby and P. De Weer 2002 Single ion occupancy and Steady-state gating of Na channels in squid giant axon. J. Gen. Physiol.119:235-249 pdf
P. De Weer, D.C. Gadsby, and R.F. Rakowski. 2001Voltage dependence of the apparent affinity for external Na+ of the backward-running sodium pump. J. Gen. Physiol. 117:315-328 pdf
L. Csanady, K.W. Chan, D. Seto-Young, D.C. Kopsco, A.C. Nairn, and D.C. Gadsby. 2000Severed channels probe regulation of gating of CFTR by its cytoplasmic domains. J. Gen. Physiol. 116:477-500 pdf
K.W. Chan, L. Csanády, D. Seto-Young, A.C. Nairn, and D.C. Gadsby. 2000Severed molecules functionally define the boundaries of CFTR's NH2-terminal nucleotide binding domain. J. Gen. Physiol. 116:163-180pdf
P. De Weer, D.C. Gadsby, and R.F. Rakowski. 2000The Na/K-ATPase: a current-generating enzyme. Na/K-ATPase and related ATPases.K. Taniguchi and S. Kaya, eds. Elsevier Science B.V., Amsterdam. pp27-34
D.C. Gadsby 2000New optical methods in cell physiology; Meeting summary. J. Gen. Physiol. 115:223-226pdf
M. Holmgren, J. Wagg, F. Bezanilla, R.F. Rakowski, P. De Weer, and D.C. Gadsby 2000Three distinct and sequential steps in the release of sodium ions by the Na+/K+ATPase. Nature. 403:898-901pdf
L. Csanády and D.C. Gadsby 1999CFTR Channel gating: incremental progress in irreversible steps. J. Gen. Physiol. 114:49-53pdf
D.C. Gadsby and A.C. Nairn 1999 Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis. Physiol. Revs. 79:S77-S107pdf
D.C. Gadsby and A.C. Nairn 1999Regulation of CFTR Cl- ion channels by phosphorylation and dephosphorylation. In Ion Channel Regulation. D.L. Armstrong and S.S. Rossie, eds. New York: Academic Press; Advances in Second Messenger and Phosphoprotein Research. Vol. 33:79-106
D.C. Gadsby, A.G. Dousmanis and A.C. Nairn 1998 ATP hydrolysis cycles and the gating of CFTR Cl- channels. Acta Physiologica Scandinavia 163, Suppl 643:247-25679:S77-S107
J. Wagg and D.C. Gadsby 1997Ordered interaction of ions with Na/K-pump may confound interpretation of unidirectional fluxes. In Na/K-ATPase & Related Transport ATPases. L.A. Beaugé, D.C. Gadsby and P.J. Garrahan, eds. Annals of the New York Academy of Sciences, 834:426-431
R.F. Rakowski, F. Bezanilla, P. De Weer, D.C. Gadsby, M. Holmgren and J. Wagg 1997Charge translocation by the Na/K pump. In Na/K-ATPase & Related Transport ATPases. L.A. Beaugé, D.C. Gadsby and P.J. Garrahan, eds. Annals of the New York Academy of Sciences, 834:231-243.
A.E. Senior and D.C. Gadsby 1997ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR. Seminars in Cancer Biology. 8:143-150
R.F. Rakowski, D.C. Gadsby, and P. De Weer 1997Voltage Dependence of the Na/K Pump. J. Membrane Biol. 155:105-112.pdf
D.C. Gadsby and A.C. Nairn 1996Regulation of CFTR channel activity. Cystic Fibrosis-Current Topics, Volume 3. J.A. Dodge, D.J.H. Brock, J.H. Widdicombe, eds. Chichester: John Wiley. pp 65-90.
D.C. Gadsby 1996 Two-bit anion channel really shapes up. Nature. 383:295-296.
D.C. Gadsby, T-C. Hwang, G. Nagel, T. Baukrowitz, M. Horie and A.C. Nairn 1995 Regulation of the gating of cardiac CFTR chloride ion channels by PKA phosphorylation and ATP hydrolysis. Heart and Vessels, Suppl. 9: Proc. TokyoWomen's Medical College International Symposium. Suppl. 9:34-37.
D.C. Gadsby, G.A. Nagel and T-C. Hwang 1995 The CFTR chloride channel of mammalian heart. Annu. Rev. Physiol. 57:387-416.
D.C. Gadsby and A.C. Nairn 1994 Regulation of CFTR channel gating. TIBS19:513-518.
D.C. Gadsby, T-C. Hwang, T. Baukrowitz, G. Nagel, M. Horie and A.C. Nairn 1994 Regulation of CFTR channel gating. Japan . J. Physiol. Suppl. 2:S183-S192.
D.C. Gadsby, T-C. Hwang, G. Nagel, T. Baukrowitz, M. Horie and A.C. Nairn 1994 Function of CFTR chloride channels expressed in mammalian cardiac myocytes. Japanese Heart Journal. Vol. 35 Suppl.: 63-68.
T. Baukrowitz, T-C. Hwang, A.C. Nairn and D.C. Gadsby 1994 Coupling of CFTR Cl channel gating to an ATP hydrolysis cycle. Neuron 12:473-482.
T-C. Hwang, G.A. Nagel, A.C. Nairn and D.C. Gadsby 1994 Regulation of the gating of CFTR Cl channels by phosphorylation and ATP hydrolysis. Proc. Natl. Acad. Sci. USA. 91: 4698-4702. pdf
P. De Weer, R.F. Rakowski and D.C. Gadsby 1994 Voltage sensitivity of the Na,K Pump: Structural implications. 7th Int Sodium Pump Conference. E. Bamberg, W. Schoner, eds. Steinkopf Verlag, Darmstadt. pp 472-481.
T-C. Hwang and D.C. Gadsby 1994 Chloride ion channels in mammalian heart cells. Curr. Top. Membr, 47: 317-346.
D.C. Gadsby, T-C. Hwang, M. Horie, G.A. Nagel and A.C. Nairn 1993 Cardiac Cl channels: incremental regulation by phosphorylation/dephosphorylation. Ann. N.Y. Acad. Sci. 707:259-274.
D.C. Gadsby, R.F. Rakowski and P. De Weer 1993 Extracellular access to the Na,K Pump: Pathway similar to ion channel. Science. 260:100-103.
T-C. Hwang, M. Horie and D.C. Gadsby 1993 Functionally distinct phospho-forms underlie incremental activation of PKA-regulated Cl- conductance in mammalian heart. J. Gen. Physiol. 101:629-650.
G.A. Nagel, T-C. Hwang, K.L. Nastiuk, A.C. Nairn and D.C. Gadsby 1992 The protein kinase A-regulated cardiac Cl- channel resembles the cystic fibrosis transmembrane conductance regulator . Nature. 360:81-84.
D.C. Gadsby, M Nakao, A. Bahinski, G. Nagel and M. Suenson 1992 Charge movements via the cardiac Na,K-ATPase. Acta Physiologica Scandinavia. 46:111-123
T-C. Hwang, M. Horie, A.C. Nairn and D.C. Gadsby 1992 Role of GTP-Binding proteins in the regulation of mammalian cardiac chloride conductance. J. Gen. Physiol. 99:465-489.
M. Horie, T-C. Hwang and D.C. Gadsby 1992 Pipette GTP is essential for receptor-mediated regulation of Cl-current in dialysed myocytes from guinea-pig ventricle J. Physiol. 455:235-246.
D. Hilgemann, G. Nagel and D.C. Gadsby 1991 Na/K pump currents in giant membrane patches excised from ventricular myocytes. In: The Sodium Pump: Recent Developments. P. De Weer & J.H. Kaplan, eds. Rockefeller University Press. pp. 543-547
D.C. Gadsby, M. Nakao and A. Bahinski 1991 Voltage-induced Na/K pump charge movements in dialyzed heart cells. In: The Sodium Pump: Structure, Mechanism, and Regulation. P. De Weer & J.H. Kaplan, eds. Rockefeller University Press. pp 355-371.
D.C. Gadsby, M. Noda, R.N. Shepherd and M. Nakao 1991 Influence of external monovalent cations on Na/Ca exchange current-voltage relationships in cardiac myocytes. Ann. N.Y. Acad. Sci. 639:140-146.
R.F. Rakowski, D.C. Gadsby and P. De Weer 1991 Voltage clamp measurement of steady-state currents and isotope flux. In: Methods in Neurosciences, Vol.4: Electrophysiology and Microinjection. P.M. Conn, ed. New York, Academic Press. pp 81-94.
D.C. Gadsby, M. Lieberman and A. Noma 1990 A tribute to Hiroshi Irisawa. J.Mol. Cell. Cardiol. 22:(4).
D.C. Gadsby 1990 Effects of ß-adrenergic catecholamines on membrane currents in cardiac cells. Cardiac Electrophysiology: A Textbook. M.R. Rosen, M.J. Janse, and A.L. Wit (eds). Mt. Kisco, N.Y., Futura. pp 857-876.
D.C. Gadsby 1990 The Na/K pump of cardiac myocytes. CardiacElectrophysiology, from Cell to Bedside D.P. Zipes, J. Jalife (eds). W.B. Saunders Co., New York. pp 35-50.
D.C. Gadsby, M. Nakao and A. Bahinski 1989 Voltage dependence of transient and steady-state Na/K pump currents in myocytes. Molecular and Cellular Biochemistry. 89:141-146.
Nakao M. and D.C. Gadsby 1989 [Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea-pig ventricular myocytes J. Gen. Physiol. 94:539-565.
D.C. Gadsby and M. Nakao 1989 Steady-state current-voltage relationship of the Na/K pump in guinea-pig ventricular myocytes. J. Gen. Physiol.94:511-537.
A. Bahinski, A.C. Nairn, P. Greengard and D.C. Gadsby 1989 Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes Nature. 340:718-721.
R.F. Rakowski, D.C. Gadsby and P. De Weer 1989 Stoichiometry and voltage-dependence of the sodium pump in voltage-clamped, internally-dialyzed squid giant axon. J. Gen. Physiol. 93:903-941.
D.C. Gadsby, A. Bahinski and M. Nakao 1989 Voltage dependence of sodium/potassium pump current. Cellular and Molecular Biology of Cell Sodium. S.G.Schultz (ed). Academic Press, New York. Curr. Top. Membr. Transp. 34:269- 288.
P. De Weer, D.C. Gadsby and R.F. Rakowski 1988 Stoichiometry and voltage dependence of the sodium pump. The Na+,K+ -Pump, Part A: Molecular Aspects. J. C. Skou, J. G. Nĝrby, A. B. Maunsbach, and M. Esmann, editors. Alan Liss, New York. pp 421-434.
A. Bahinski, D.C. Gadsby and M. Nakao 1988 Potassium translocation by the Na/K pump is voltage insensitive. Proc. Natl. Acad. Sci. USA. 85:3412-3416.
A. Bahinski and D.C. Gadsby 1988 Current-voltage relationship of the backward-running Na/K pump in isolated cells from guinea-pig ventricle. Biology of Isolated Adult Cardiac Myocytes. W.A. Clark, R.S. Decker and T.K. Borg (eds). Elsevier Science Publishing Co., Inc. New York, N.Y., pp.430-433.
P. De Weer, D.C. Gadsby and R.F. Rakowski 1988 Voltage dependence of the Na/K pump. Ann. Rev. Physiol. 50: 225-241.
D.C. Gadsby and A.L. Wit 1987 Normal and abnormal electrical activity in cardiac cells. Cardiac Arrhythmias: Their Mechanisms, Diagnosis, and Management. Second Edition. W.J. Mandel, (ed). Lippincott, Philadelphia, pp. 53-80.
M. Nakao and D.C. Gadsby 1986 Voltage dependence of Na translocation by the Na/K pump. Nature. 323: 628-630.
R.F. Rakowski, P. De Weer and D.C. Gadsby 1985 Voltage dependence of backward-running Na+ pump in squid giant axons. The Sodium Pump. I.M. Glynn and J.C. Ellory, (eds). The Company of Biologists, Cambridge, U.K., pp. 511- 515.
D.C. Gadsby, J. Kimura and A. Noma 1985 Voltage dependence of Na/K pump current in isolated heart cells. Nature. 315: 63-65.
D.C. Gadsby 1985 Influence of Na/K pump current on action potentials in Purkinje fibers. Advances in Myocardiology, vol. 5. P. Harris, P.A. Poole-Wilson (eds). Plenum, New York, pp. 279-294.
D.C. Gadsby 1984 The Na/K pump of cardiac cells. Ann. Rev. Biophys. Bioeng. 13:373-398.
D.C. Gadsby 1984 Influence of the sodium pump current on electrical activity of cardiac cells. Electrogenic Transport: Fundamental Principles and Physiological Implications. M.P. Blaustein, M. Lieberman (eds). Raven Press, New York, pp. 215-238.
D.C. Gadsby 1983 ß-adrenoceptor agonists increase membrane K conductance in cardiac Purkinje fibres. Nature. 306:691-693.
P.A. Boyden, P.F. Cranefield and D.C. Gadsby 1983 Noradrenaline hyperpolarizes cells of the canine coronary sinus by increasing their permeability to potassium ions. J. Physiol. (Lond.) 339:185-206.
P.A. Boyden, P.F. Cranefield, D.C. Gadsby and A.L. Wit 1983 The basis for the membrane potential of quiescent cells of the canine coronary sinus. J. Physiol. (Lond.) 339:161-183.
D.C. Gadsby and P.F. Cranefield 1982 Effects of electrogenic sodium extrusion on the membrane potential of cardiac Purkinje fibers. Normal and Abnormal Conduction in the Heart. B.F. Hoffman, M. Lieberman, A. Paes de Carvalho (eds). Futura, Mt. Kisco, New York, pp. 225-247.
D.C. Gadsby 1982 Review of Ion Transport in Heart by L.J. Mullins. Ther. Drug Monit. 4:329-330
D.C. Gadsby 1982 Hyperpolarization of frog skeletal muscle fibers and of canine cardiac Purkinje fibers during enhanced Na+/K+ exchange: extracellular K+ depletion, or increased pump current? Curr. Top. Membr. Transp. 16:17-34
A.L. Wit, P.F. Cranefield and D.C. Gadsby 1981 Electrogenic sodium extrusion can stop triggered activity in the canine coronary sinus. Circ. Res. 49:1029-1042.
D.C. Gadsby and A.L. Wit 1981 Electrophysiological characteristics of cardiac cells and the genesis of cardiac arrhythmias. Cardiac Pharmacology. R.D. Wilkerson (ed), Academic Press, New York, pp. 229-274.
A.L. Wit, P.F. Cranefield and D.C. Gadsby 1980 Triggered activity. The Slow inward current. D.P. Zipes (ed), Martinus Nijhoff, The Hague, Holland, pp. 437-454.
D.C. Gadsby 1980 Activation of electrogenic Na+/K+ exchange by extracellular K+ in canine cardiac Purkinje fibers. Proc. Natl. Acad. Sci. USA. 77:4035-4039.
D.C. Gadsby and A.L. Wit 1980 Normal and abnormal electrical activity in cardiac cells. Cardiac Arrhythmias: Their Mechanisms, Diagnosis, and Management. W.J. Mandel (ed). Lippincott, Philadelphia, pp. 53-80.
A.L. Wit, P.A. Boyden, D.C. Gadsby and P.F. Cranefield 1979 Triggered activity as a cause of atrial arrhythmias. Cardiac Arrhythmias: Electrophysiology, Diagnosis and Management. O.S. Narula (ed), Williams and Wilkins, Baltimore, pp. 14-31.
D.C. Gadsby and P.F. Cranefield 1979 Electrogenic sodium extrusion in cardiac Purkinje fibers. J. Gen. Physiol. 73:819-837.
D.C. Gadsby and P.F. Cranefield 1979 Direct measurement of changes in sodium pump current in canine cardiac Purkinje fibers. Proc. Natl. Acad. Sci. USA. 76:1783-1787.
D.C. Gadsby, A.L. Wit and P.F. Cranefield 1978 The effects of acetylcholine on the electrical activity of canine Purkinje fibers. Circ. Res. 43:29-35.
D.C. Gadsby 1978 Active and Passive Components of the Muscle Membrane Potential in the Frog. Ph.D. thesis, University College London.
D.C. Gadsby and P.F. Cranefield 1977 Two levels of resting potential in cardiac Purkinje fibers. J. Gen. Physiol. 70:725-746.
D.C. Gadsby, R. Niedergerke and D.C. Ogden 1977 The dual nature of the membrane potential increase associated with the activity of the sodium/potassium exchange pump in skeletal muscle fibres. Proc. Roy. Soc. Lond. Ser. B. Biol. Sci. 198: 463-472.
D.C. Gadsby, R. Niedergerke and S. Page 1971 Do intracellular concentrations of potassium or sodium regulate the strength of the heart beat? Nature (London) 232:651-653.

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