Top, Simplified scheme illustrating proposed linking of steps in CFTR channel gating with ATP binding and hydrolysis. Bottom , Cartoon illustrating possible physical interpretation of scheme: nucleotide binding domain (NBD) dimerization couples ATP binding and hydrolysis at the catalytic site(s) to opening and closing of channel pore. The NBDs are represented as green (NBD1) or blue (NBD2) ovals/comma shapes, and the two TMDs are shown as straight line segments, converging in Closed, and near-parallel in Open state.

Click To Close