Rockefeller University

The Rockefeller University
1230 York Avenue
New York, NY 10021

Curriculum Vitae
David C. Gadsby, Professor

D.W. Bronk Building, Room 307
Tel: (212)327-8617 Fax: (212)327-7589


Major Research Interest:

Molecular mechanisms of active and passive ion transport across cell membranes.

Education:

1966-1969: Trinity College, Cambridge: Natural Sciences Tripos-Physiology/ Biophysics Part II, B.A. hons. (1969), M.A. (1973)
1969-1975: Department of Biophysics, University College London, Ph.D. in Physiology (1978)

Positions Held:

1969-1975: Associate Research Assistant with Dr. R. Niedergerke, Department of Biophysics, University College London
1975-1978: Research Associate with Prof. P.F. Cranefield, Laboratory of CardiacPhysiology, The Rockefeller University, New York
1978-1984: Assistant Professor, Laboratory of Cardiac Physiology, The Rockefeller University
1980-1991: Adjunct Assistant/Associate Professor, Department of Physiology and Biophysics, Cornell University Medical College, New York
1984        : JSPS Invited Scientist, Natnl. Inst. for Physiological Sciences, National Research Institutes, Okazaki, Japan
1984-1991: Associate Professor, Laboratory of Cardiac Physiology, The Rockefeller University
1991        : Professor & Head, Laboratory of Cardiac/Membrane Physiology, The Rockefeller University
1991        : Adjunct Professor, Department of Physiology and Biophysics, Cornell University Medical College, New York
2001        : Benjamin Beaker Visiting Professor, Univerty of Bristol School of Medical Sciences, Bristol, UK

Professional Activities, Honours, and Awards:

1981-1986:Established Fellowship of the New York Heart Association
1981-1984:Editorial Board: Journal of General Physiology
1983        :Steps Towards Independence Fellowship, MBL, Woods Hole
1983        :Stephen W. Kuffler Fellow, MBL, Woods Hole
1983-1987:Research Peer Review Committee, New York Heart Association
1984        :Associate Editor: Journal of General Physiology
1986-1991:Irma T. Hirschl Career Scientist Award
1986        :Distinguished Leadership in Education Award, School Board Two, NYC
1989-1992:American Heart Association, National Cellular Physiology & Pharmacology Research Study Committee
1989-1997:New York Academy of Sciences, Conference Committee
1991        : Chairman, Membrane Biophysics Subgroup, Biophysical Society
1993-1998:Research Council, New York Heart Association
1995        : K. S. Cole Award, Membrane Biophysics Subgroup, Biophysical Society
1994-1998:Member (Chair 1996-1998), NIH Physiology Study Section
1994-1996:Society of General Physiologists, Council Member
1998-2000:NIH Heart, Lung, & Blood Institute MERIT Award
1999-2000:President, Society of General Physiologists
2000        :Chairman, Gordon Research Conference, Ion Channels
2002-2005:Editorial Board, Physiological Reviews

Professional Societies:

  • American Association for the Advancement of Science
  • American Heart Association/New York City Affiliate
  • Biophysical Society
  • Harvey Society
  • MBL Corporation
  • New York Academy of Sciences
  • Physiological Society (U.K.)
  • Society of General Physiologists

List of Publications:


  1. D.C. Gadsby, R. Niedergerke and S. Page (1971). Do intracellular concentrations of potassium or sodium regulate the strength of the heart beat? Nature (London) 232:651-653.

  2. D.C. Gadsby, R. Niedergerke and D.C. Ogden (1977). The dual nature of the membrane potential increase associated with the activity of the sodium/potassium exchange pump in skeletal muscle fibres. Proc. Roy. Soc. Lond. Ser. B. Biol. Sci. 198: 463-472.

  3. D.C. Gadsby (1978). Active and Passive Components of the Muscle Membrane Potential in the Frog. Ph.D. thesis, University College London.

  4. D.C. Gadsby and P.F. Cranefield (1977). Two levels of resting potential in cardiac Purkinje fibers. J. Gen. Physiol. 70:725-746.

  5. D.C. Gadsby, A.L. Wit and P.F. Cranefield (1978). The effects of acetylcholine on the electrical activity of canine Purkinje fibers. Circ. Res. 43:29-35.

  6. D.C. Gadsby and P.F. Cranefield (1979). Direct measurement of changes in sodium pump current in canine cardiac Purkinje fibers. Proc. Natl. Acad. Sci. USA. 76:1783-1787.

  7. D.C. Gadsby and P.F. Cranefield (1979). Electrogenic sodium extrusion in cardiac Purkinje fibers. J. Gen. Physiol. 73:819-837.

  8. A.L. Wit, P.A. Boyden, D.C. Gadsby and P.F. Cranefield (1979). Triggered activity as a cause of atrial arrhythmias. In: Cardiac Arrhythmias: Electrophysiology, Diagnosis and Management. O.S. Narula (ed), Williams and Wilkins, Baltimore, pp. 14-31.

  9. D.C. Gadsby and A.L. Wit (1980). Normal and abnormal electrical activity in cardiac cells. In: Cardiac Arrhythmias: Their Mechanisms, Diagnosis, and Management. W.J. Mandel (ed). Lippincott, Philadelphia, pp. 53-80.

  10. D.C. Gadsby (1980). Activation of electrogenic Na+/K+ exchange by extracellular K+ in canine cardiac Purkinje fibers. Proc. Natl. Acad. Sci. USA. 77:4035-4039.

  11. A.L. Wit, P.F. Cranefield and D.C. Gadsby (1980). Triggered activity. In: The Slow inward current. D.P. Zipes (ed), Martinus Nijhoff, The Hague, Holland, pp. 437-454.

  12. D.C. Gadsby and A.L. Wit (1981). Electrophysiological characteristics of cardiac cells and the genesis of cardiac arrhythmias. In: Cardiac Pharmacology. R.D. Wilkerson (ed), Academic Press, New York, pp. 229-274.

  13. A.L. Wit, P.F. Cranefield and D.C. Gadsby (1981). Electrogenic sodium extrusion can stop triggered activity in the canine coronary sinus. Circ. Res. 49:1029-1042.

  14. D.C. Gadsby (1982). Hyperpolarization of frog skeletal muscle fibers and of canine cardiac Purkinje fibers during enhanced Na+/K+ exchange: extracellular K+ depletion, or increased pump current? Curr. Top. Membr. Transp. 16:17-34

  15. D.C. Gadsby (1982). Review of Ion Transport in Heart, by L.J. Mullins. Ther. Drug Monit. 4:329-330.

  16. D.C. Gadsby and P.F. Cranefield (1982). Effects of electrogenic sodium extrusion on the membrane potential of cardiac Purkinje fibers. In: Normal and Abnormal Conduction in the Heart. B.F. Hoffman, M. Lieberman, A. Paes de Carvalho (eds). Futura, Mt. Kisco, New York, pp. 225-247.

  17. P.A. Boyden, P.F. Cranefield, D.C. Gadsby and A.L. Wit (1983). The basis for the membrane potential of quiescent cells of the canine coronary sinus. J. Physiol. (Lond.) 339:161-183.

  18. P.A. Boyden, P.F. Cranefield and D.C. Gadsby (1983). Noradrenaline hyperpolarizes cells of the canine coronary sinus by increasing their permeability to potassium ions. J. Physiol. (Lond.) 339:185-206.

  19. D.C. Gadsby (1983). ß-adrenoceptor agonists increase membrane K conductance in cardiac Purkinje fibres. Nature. 306:691-693.

  20. D.C. Gadsby (1984). Influence of the sodium pump current on electrical activity of cardiac cells. In: Electrogenic Transport: Fundamental Principles and Physiological Implications. M.P. Blaustein, M. Lieberman (eds). Raven Press, New York, pp. 215-238.

  21. D.C. Gadsby (1984). The Na/K pump of cardiac cells. Ann. Rev. Biophys. Bioeng. 13:373-398.

  22. D.C. Gadsby (1985). Influence of Na/K pump current on action potentials in Purkinje fibers. In: Advances in Myocardiology, vol. 5. P. Harris, P.A. Poole-Wilson (eds). Plenum, New York, pp. 279-294.

  23. D.C. Gadsby, J. Kimura and A. Noma (1985). Voltage dependence of Na/K pump current in isolated heart cells. Nature 315: 63-65.

  24. R.F. Rakowski, P. De Weer and D.C. Gadsby (1985). Voltage dependence of backward-running Na + pump in squid giant axons. In: The Sodium Pump. I.M. Glynn and J.C. Ellory, (eds). The Company of Biologists, Cambridge, U.K., pp. 511- 515.

  25. M. Nakao and D.C. Gadsby (1986). Voltage dependence of Na translocation by the Na/K pump. Nature 323: 628-630.

  26. D.C. Gadsby and A.L. Wit (1987). Normal and abnormal electrical activity in cardiac cells. In: Cardiac Arrhythmias: Their Mechanisms, Diagnosis, and Management. Second Edition. W.J. Mandel, (ed). Lippincott, Philadelphia, pp. 53-80.

  27. P. De Weer, D.C. Gadsby and R.F. Rakowski (1988). Voltage dependence of the Na/K pump. Ann. Rev. Physiol. 50: 225-241.

  28. A. Bahinski and D.C. Gadsby (1988). Current-voltage relationship of the backward-running Na/K pump in isolated cells from guinea-pig ventricle. In: Biology of Isolated Adult Cardiac Myocytes. W.A. Clark, R.S. Decker and T.K. Borg (eds). Elsevier Science Publishing Co., Inc. New York, N.Y., pp.430-433.

  29. A. Bahinski, D.C. Gadsby and M. Nakao (1988). Potassium translocation by the Na/K pump is voltage insensitive. Proc. Natl. Acad. Sci. USA. 85:3412-3416.

  30. P. De Weer, D.C. Gadsby and R.F. Rakowski (1988). Stoichiometry and voltage dependence of the sodium pump. In: The Na+,K+ -Pump, Part A: Molecular Aspects. J. C. Skou, J. G. Nĝrby, A. B. Maunsbach, and M. Esmann, editors. Alan Liss, New York. pp 421-434.
  31. D.C. Gadsby, A. Bahinski and M. Nakao (1989). Voltage dependence of sodium/potassium pump current. In: Cellular and Molecular Biology of Cell Sodium. S.G.Schultz (ed). Academic Press, New York. Curr. Top. Membr. Transp. 34:269- 288.

  32. R.F. Rakowski, D.C. Gadsby and P. De Weer (l989). Stoichiometry and voltage-dependence of the sodium pump in voltage-clamped, internally-dialyzed squid giant axon. J. Gen. Physiol. 93:903-941.

  33. A. Bahinski, A.C. Nairn, P. Greengard and D.C. Gadsby (1989). Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes. Nature. 340:718-721.

  34. D.C. Gadsby and M. Nakao (l989). Steady-state current-voltage relationship of the Na/K pump in guinea-pig ventricular myocytes. J. Gen. Physiol. 94:511-537.

  35. Nakao M. and D.C. Gadsby (l989). [Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea-pig ventricular myocytes J. Gen. Physiol. 94:539-565.

  36. D.C. Gadsby, M. Nakao and A. Bahinski (1989). Voltage dependence of transient and steady-state Na/K pump currents in myocytes. Molecular and Cellular Biochemistry. 89:141-146.

  37. D.C. Gadsby (1990). The Na/K pump of cardiac myocytes. In: Cardiac Electrophysiology, from Cell to Bedside. D.P. Zipes, J. Jalife (eds). W.B. Saunders Co., New York. pp 35-50.

  38. D.C. Gadsby (1990). Effects of ß-adrenergic catecholamines on membrane currents in cardiac cells. In: Cardiac Electrophysiology: A Textbook. M.R. Rosen, M.J. Janse, and A.L. Wit (eds). Mt. Kisco, N.Y., Futura. pp 857-876.

  39. D.C. Gadsby, M. Lieberman and A. Noma (1990). A tribute to Hiroshi Irisawa. J. Mol. Cell. Cardiol. 22:(4).

  40. R.F. Rakowski, D.C. Gadsby and P. De Weer (l991). Voltage clamp measurement of steady-state currents and isotope flux. In: Methods in Neurosciences, Vol.4: Electrophysiology and Microinjection. P.M. Conn, ed. New York, Academic Press. pp 81-94.

  41. D.C. Gadsby, M. Noda, R.N. Shepherd and M. Nakao (1991). Influence of external monovalent cations on Na/Ca exchange current-voltage relationships in cardiac myocytes. Ann. N.Y. Acad. Sci. 639:140-146.

  42. D.C. Gadsby, M. Nakao and A. Bahinski (1991). Voltage-induced Na/K pump charge movements in dialyzed heart cells. In: The Sodium Pump: Structure, Mechanism, and Regulation. P. De Weer & J.H. Kaplan, eds. Rockefeller University Press. pp 355-371.

  43. D. Hilgemann, G. Nagel and D.C. Gadsby (1991). Na/K pump currents in giant membrane patches excised from ventricular myocytes. In: The Sodium Pump: Recent Developments. P. De Weer & J.H. Kaplan, eds. Rockefeller University Press. pp. 543-547.

  44. M. Horie, T-C. Hwang and D.C. Gadsby (1992). Pipette GTP is essential for receptor-mediated regulation of Cl- current in dialysed myocytes from guinea-pig ventricle. J. Physiol. 455:235-246.

  45. T-C. Hwang, M. Horie, A.C. Nairn and D.C. Gadsby (1992). Role of GTP-Binding proteins in the regulation of mammalian cardiac chloride conductance. J. Gen. Physiol. 99:465-489.

  46. D.C. Gadsby, M Nakao, A. Bahinski, G. Nagel and M. Suenson (1992). Charge movements via the cardiac Na,K-ATPase. Acta Physiologica Scandinavia. 46:111- 123.

  47. G.A. Nagel, T-C. Hwang, K.L. Nastiuk, A.C. Nairn and D.C. Gadsby (1992). The protein kinase A-regulated cardiac Cl- channel resembles the cystic fibrosis transmembrane conductance regulator Nature 360:81-84.

  48. T-C. Hwang, M. Horie and D.C. Gadsby (1993). Functionally distinct phospho-forms underlie incremental activation of PKA-regulated Cl- conductance in mammalian heart. J. Gen. Physiol. 101:629-650.

  49. D.C. Gadsby, R.F. Rakowski and P. De Weer (l993). Extracellular access to the Na,K Pump: Pathway similar to ion channel. Science 260:100-103.

  50. D.C. Gadsby, T-C. Hwang, M. Horie, G.A. Nagel and A.C. Nairn (1993). Cardiac Cl channels: incremental regulation by phosphorylation/dephosphorylation. Ann. N.Y. Acad. Sci. 707:259-274.

  51. T-C. Hwang and D.C. Gadsby (1994). Chloride ion channels in mammalian heart cells. Curr. Top. Membr, 47: 317-346.

  52. P. De Weer, R.F. Rakowski and D.C. Gadsby (l994). Voltage sensitivity of the Na,K Pump: Structural implications. 7th Int Sodium Pump Conference. E. Bamberg, W. Schoner, eds. Steinkopf Verlag, Darmstadt. pp 472-481.

  53. T-C. Hwang, G.A. Nagel, A.C. Nairn and D.C. Gadsby (1994). Regulation of the gating of CFTR Cl channels by phosphorylation and ATP hydrolysis. Proc. Natl. Acad. Sci. USA. 91: 4698-4702.

  54. T. Baukrowitz, T-C. Hwang, A.C. Nairn and D.C. Gadsby (1994). Coupling of CFTR Cl channel gating to an ATP hydrolysis cycle. Neuron 12:473-482.

  55. D.C. Gadsby, T-C. Hwang, G. Nagel, T. Baukrowitz, M. Horie and A.C. Nairn (1994). Function of CFTR chloride channels expressed in mammalian cardiac myocytes. Japanese Heart Journal. Vol. 35 Suppl.: 63-68.

  56. D.C. Gadsby, T-C. Hwang, T. Baukrowitz, G. Nagel, M. Horie and A.C. Nairn (1994). Regulation of CFTR Channel Gating. Japan . J. Physiol. Suppl. 2:S183-S192.

  57. D.C. Gadsby and A.C. Nairn (1994). Regulation of CFTR channel gating. TIBS 19:513-518.

  58. D.C. Gadsby, G.A. Nagel and T-C. Hwang (1995). The CFTR chloride channel of mammalian heart. Annu. Rev. Physiol. 57:387-416.

  59. D.C. Gadsby, T-C. Hwang, G. Nagel, T. Baukrowitz, M. Horie and A.C. Nairn (1995). Regulation of the gating of cardiac CFTR chloride ion channels by PKA phosphorylation and ATP hydrolysis. Heart and Vessels, Suppl. 9: Proc. Tokyo Women's Medical College International Symposium. Suppl. 9:34-37.

  60. D.C. Gadsby (1996). Two-bit anion channel really shapes up. Nature. 383: 295-296.

  61. D.C. Gadsby and A.C. Nairn (1996). Regulation of CFTR channel activity. In Cystic Fibrosis-Current Topics, Volume 3. J.A. Dodge, D.J.H. Brock, J.H. Widdicombe, eds. Chichester: John Wiley. pp 65-90.

  62. R.F. Rakowski, D.C. Gadsby, and P. De Weer (1997). Voltage Dependence of the Na/K Pump. J. Membrane Biol. 155:105-112.

  63. A.E. Senior and D.C. Gadsby (1997). ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR. Seminars in Cancer Biology. 8:143-150.

  64. R.F. Rakowski, F. Bezanilla, P. De Weer, D.C. Gadsby, M. Holmgren and J. Wagg (1997). Charge translocation by the Na/K pump. In Na/K-ATPase & Related Transport ATPases. L.A. Beaugé, D.C. Gadsby and P.J. Garrahan, eds. Annals of the New York Academy of Sciences, 834:231-243.

  65. J. Wagg and D.C. Gadsby (1997). Ordered interaction of ions with Na/K-pump may confound interpretation of unidirectional fluxes. In Na/K-ATPase & Related Transport ATPases. L.A. Beaugé, D.C. Gadsby and P.J. Garrahan, eds. Annals of the New York Academy of Sciences, 834:426-431.

  66. D.C. Gadsby, A.G. Dousmanis and A.C. Nairn (1998). ATP hydrolysis cycles and the gating of CFTR Cl- channels. Acta Physiologica Scandinavia, 163, Suppl 643:247- 256.

  67. D.C. Gadsby and A.C. Nairn (1999). Regulation of CFTR Cl- ion channels by phosphorylation and dephosphorylation. In Ion Channel Regulation. D.L. Armstrong and S.S. Rossie, eds. New York: Academic Press; Advances in Second Messenger and Phosphoprotein Research, Vol. 33:79-106.

  68. D.C. Gadsby and A.C. Nairn (1999). Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis. Physiol. Revs., 79:S77-S107.

  69. L. Csanády and D.C. Gadsby (1999). CFTR Channel gating: incremental progress in irreversible steps. J. Gen. Physiol., 114:49-53.

  70. M. Holmgren, J. Wagg, F. Bezanilla, R.F. Rakowski, P. De Weer, and D.C. Gadsby (2000). Three distinct and sequential steps in the release of sodium ions by the Na+/K+ATPase. Nature. 403:898-901.

  71. D.C. Gadsby (2000). New optical methods in cell physiology; Meeting summary. J. Gen. Physiol. 115:223-226

  72. P. De Weer, D.C. Gadsby, and R.F. Rakowski (2000). The Na/K-ATPase: a current-generating enzyme. In Na/K-ATPase and related ATPases. K. Taniguchi and S. Kaya, eds. Elsevier Science B.V., Amsterdam. pp27-34

  73. K.W. Chan, L. Csanády, D. Seto-Young, A.C. Nairn, and D.C. Gadsby (2000). Severed molecules functionally define the boundaries of CFTR's N-terminal nucleotide binding domain. J. Gen. Physiol. 116:163-180.

  74. L. Csanady, K.W. Chan, D. Seto-Young, D.C. Kopsco, A.C. Nairn, and D.C. Gadsby. (2000). Severed channels probe regulation of gating of CFTR by its cytoplasmic domains. J. Gen. Physiol. 116:477-500.

  75. P. De Weer, D.C. Gadsby, and R.F. Rakowski (2001).Voltage dependence of the apparent affinity for external Na+ of the backward-running sodium pump.J. Gen. Physiol. 1167:315-328

    Book:
  76. L.A. Beaugé, D.C. Gadsby and P.J. Garrahan. (1997) Na/K-ATPase & Related Transport ATPases. New York: Annals of the New York Academy of Sciences, Vol 834, 694pp.



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