Publications
- Ahn HJ, Zamolodchikov D, Cortes-Canteli M, Norris EH, Glickman JF, Strickland S. Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21812-7. Epub 2010 Nov 22. PubMed PMID: 21098282; PubMed Central PMCID: PMC3003082.
- Smirnova NA, Rakhman I, Moroz N, Basso M, Payappilly J, Kazakov S, Hernandez-Guzman F, Gaisina IN, Kozikowski AP, Ratan RR, Gazaryan IG. (2010) Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chem Biol.Apr 23;17(4):380-91. PMID: 20416509.
- Lin, G.; Li, D.; Sorio de Carvalho, L. P.; Deng, H.; Tao, H.; Vogt, G.; Wu, K.; Schneider, J.; Chidawanyika, T.; Warren, J. D.; Li, H.; Nathan, C. (2009) Inhibitors Selective for Mycobacterial versus Human Proteasomes" Nature, DOI: 10.1038/nature08357
- Hotha S, Yarrow JC, Yang JG, Garrett S, Renduchintala KV, Mayer TU, Kapoor TM. (2003) HR22C16: a potent small-molecule probe for the dynamics of cell division Angew Chem Int Ed Engl.May 30;42(21):2379-82
- Hess, K.C.*, Jones, B.H.*, Marquez, B., Chen, Y., Ord, T.S., Kamenetsky, M., Myamoto, C., Zippin, J.H., Kopf, G.S., Suarez, S.S., Levin, L.R.*, Williams, C.J.*, Buck, J.*, and Moss, S.B.* (2005). 'Soluble' Adenylyl Cyclase mediates Multiple Specific Signaling Events in Sperm Required for Fertilization. Dev. Cell 9: 249-259.
- Han, H., Stessin, A.M., Roberts, J., Hess, K.C., Gautam, N., Kamenetsky, M., Lou, O., Hyde, E., Nathan, N., Muller, W.A., Buck, J., Levin, L.R., and Nathan, C. (2005). Role of Calcium-Sensing Soluble Adenylyl Cyclase in TNF Signal Transduction in Human Neutrophils. J. Exp. Med. 202: 353-361.
- Peters U, Cherian J, Kim JH, Kwok BH, Kapoor TM. (2006) Probing cell-division phenotype space and Polo-like kinase function using small molecules Nat Chem Biol. Nov;2(11):618-26.
- Pipalia NH, Huang A, Ralph H, Rujoi M, Maxfield FR (2006) Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells. J Lipid Res. Feb;47(2):284-301
- Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G. Synthesis of a red-shifted fluorescence polarization probe for Hsp90. Bioorg. (2006) Med. Chem. Lett., (16):4515-4518.
- Wu, K.Y., Zippin, J.H., Huron, D.R., Kamenetsky, M., Hengst, U., Buck, J., Levin, L.R., and Jaffrey, S.R. (2006). Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nature Neuroscience. 9: 1257-1264.
- Blue R, Murcia M, Karan C, Jirousková M, Coller BS. Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen. (2008) Blood. Feb 1;111(3):1248-56
- Kenneth D. Bromberg, Avi Ma'ayan, Susana R. Neves, Ravi Iyengar* Design Logic of a Cannabinoid Receptor Signaling Network That Triggers Neurite Outgrowth (2008) Science 320, 903
- Farrell, J.*, Ramos, L.*, Tresguerres, M., Kamenetsky, M., Levin, L.R., and Buck, J. (2008). Somatic 'Soluble' adenylyl cyclase isoforms are unaffected in Sacytm1Lex/Sacytm1Lex 'Knockout' mice. PLoS ONE 3(9) e3251.
- Ramos, L.*, Zippin, J.H.*, Kamenetsky, M., Buck, J., and Levin, L.R. (2008). Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J. Gen. Physiol. 132: 329-338.
- Chiosis G, Kang Y, Sun W. Discovery and development of purine-scaffold Hsp90 inhibitors. (2008) Expert Opin. Drug Disc. 3(1):99-114.
- Kang Y, Taldone T, Clement CC, Fewell SW, Aguirre J, Brodsky JL, Chiosis G. (2008) Design of a fluorescence polarization assay platform for the study of human Hsp70. Bioorg Med Chem Lett. Jul 1;18(13):3749-
- Rodina A, Kang Y, Maharaj R, Gozman A, Taldone T, Caldas-Lopes EM, Clement CC, Brodsky J, Ma Y, Gross SS, Cerchietti L, Melnick A, Freeman BC, Cox MB, Young JC, Chen E, Chirico W, Chiosis G. (2009) Probing malignancy through a novel small molecule heat shock protein 70 modulator. In review Nature chemical biology
- Porotto M, Orefice G, Yokoyama CC, Mungall BA, Realubit R, Sganga ML, Aljofan M, Whitt M, Glickman F, Moscona A. (2009) Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy J Virol.;83(10):5148-55
- Glickman, J. F. (2009) Assay Development for Protein Kinases and Phosphatases. In A Practical guide to Assay Development for High Throughput Screening Taosheng Chen, ed., Taylor and Francis Publishers, London.
