Fiscal Year 2012 Pricing
(July 1, 2011 to June 30, 2012)
The costs of HTS depend upon the nature and scope of the project. Fees can include compound delivery and formatting, instrument use, and technical support. An annual fee per user is requested to cover the HTS infrastructure such as databases and software and includes scientific consultations before, during and after screening and an initial training on the instruments. The fee structure is set up to encourage and support "best practice" in HTS and appropriately allocate the fees with resource use levels per user.
| FY 2012 Service | RU/WCMC Users | External Users |
|---|---|---|
| Quarterly Infrastructure Fee | $150 | $250 |
| Database Access Fee (per HTS project/quarter) | $100 | $200 |
| Technical Support (per hour) | $72 | $130 |
| Mixture Compound plate Replication (per mixture plate) | $50 | $74 |
| Biacore 3000 (per 4 hours) | $40 | $80 |
| AutoITC200 (per 4 hours) | $40 | $80 |
| Compound Plate Replication (per 384-plate) | $25 | $37 |
| Liquid and Particle dispensers (per hour) | $21 | $41 |
| Analytical Instruments & plate readers (per hour) | $15 | $30 |
| Cherry Picking (per compound, 100 minimum) | $2 | $3 |
Typical Costs and Fees for a High-Throughput Screen of 165,000 small organic molecules
| Item | Internal | External |
|---|---|---|
| 165,000 compounds | $11,718 | $17,343 |
| 20 hours Tech Support | $1,440 | $2,600 |
| 25 hours plate reader time | $375 | $750 |
| 60 hours liquid dispenser time | $1,260 | $2,460 |
| Concentration response curves for 500 compounds | $1,000 | $1,500 |
| 3 quarterly fees | $450 | $750 |
| 3 database fees | $300 | $600 |
| Total | $16,543 | $26,003 |
Related costs not covered by above :
In addition to performing the actual screening work, the Laboratory will need to purchase appropriate screening reagents and certain disposables. These may include enzymes, detection reagents, antibodies, peptides, fluorescent molecules, specialized ELISA plates, plastic tips, and control compounds. Depending upon what types of materials are required, these costs can range from approximately $3000-$30,000. Converting a validated hit compound to a lead/tool compound can require "follow-up" chemistry and compound purchasing to conduct the required secondary and tertiary assays and custom chemical syntheses. This validation work can carry significant costs. The HTSRC offers guidance in this area.
