Academic Opportunities

Postdoctoral position in Computational Biostatistics

A postdoctoral position in computational biostatistics is available at the Rockefeller University’s CTSA-supported Center for Clinical and Translational Science in the Biostatistics, Epidemiology, and Research Design (BERD) group. The successful candidate will collaborate extensively with investigators in the Center in design and analysis of a wide range of research projects, with a special emphasis on developing new statistical methods for analysis of genomic results in Genome Wide Association Studies (GWAS) and Genome-Wide Expression Studies (GWES).

GWAS and GWES have had limited success when applied to complex diseases. Analyzing SNPs or genes individually requires several large studies to integrate the often divergent results. Traditional parametric approaches for multivariate data often have low sensitivity and generate an abundance of artifacts, while non-parametric approaches have never been fully developed, due to their high computational demand. At the RU BERD, we have extended u-statistics (Hoeffding 1948, Gehan 1965) to include information about the sequence of neighboring SNPs and information from the HapMap project about recombination hotspots (GWAS) as well as collaboration across binding sites and along pathways (GWES) to increase the power and/or reduce sample size requirements. To make these approaches feasible, we have built a grid infrastructure and developed algorithms to harness the power of graphics processing units for general purpose computing (GP2U). For publications, including applications to psoriasis (Stat Med 2004), addiction (Mol Brain Res 2004), Fanconi Anemia (SAGMB 2008), and multiple sclerosis (BMC Med Genet 2009), as well as sports (JQAS 2008) and consumer preferences (Transportation 2009), see https://appext.rockefeller.edu/facpub/do/query_pub_list?author1=wittkowski. Current projects include collaborations cancer and immunology (Krueger Lab), as well as epilepsy (Mount Sinai School of Medicine), multiple sclerosis (OxfordUniversity), and myocardial infarction (HarvardUniversity).

We are seeking a highly motivated individual who is interested in applying a whole range of statistical and computational approaches, including further work on u-statistics for multivariate data, development of massively parallel algorithms, implementation in OpenCL, and integration into a Web interface to a grid-based architecture to support clinical and translational research in these exciting times, where the computational biostatistics approaches being developed revolutionize diagnostic and therapeutic strategies.

The Rockefeller University supports a vibrant and growing research community in genetics and the successful candidate will have the opportunity to interact with leading researchers in the field. No teaching is required.

A Ph.D. in statistics or computer science or equivalent is required. Ability to think and work rigorously and skeptically, strong desire to solve problems in translational science, willingness to learn new subjects are essential, as is the ability to communicate efficiently in both spoken and written English. Additional background in biology, genetics, medicine, and related fields is desirable.

The ideal candidate for the position will have a strong background in non-parametric statistics, knowledge of php, SQL, S+/R, C, OpenCL/CUDA, and a record of successfully developed Web-based applications.

Applications will be accepted until the position is filled. The position is available immediately.

To apply, please submit the following items to Dr. Knut M. Wittkowski at: kmw@rockefeller.edu: CV, contact information for two to three references, a short cover letter (not more than one page) describing your background and research interests.

Rockefeller University is an Affirmative Action/Equal Opportunity/VEVRAA Employer and solicits applications from women and under-represented minorities

Postdoctoral position in Investigative Dermatology

A two-three year postdoctoral position is available in the Laboratory of Investigative Dermatology at Rockefeller University, working with Drs. Emma Guttman and James Krueger. The research will involve studying the immune and barrier abnormalities underlying atopic dermatitis, as well as the reversal of atopic dermatitis disease with several novel biologic therapies targeting main immune axes involved in the disease that might revolutionize treatment of atopic dermatitis, and understanding of the disease. The postdoc is truly translational in its nature. The work will be a collaboration between Mount Sinai Dermatology and Immunology Institute and the Rockefeller University, but the laboratory portion will be mainly done at the Rockefeller University, although the position will be paid by Mount Sinai or from a collaborative grant between the institutions.

The Laboratory of Investigative Dermatology is an established lab at the Rockefeller University campus on Manhattan's Upper East Side. The Mount Sinai Immunology Institute and dermatology departments are also located on the Upper East Side.  Dr. Guttman is an expert in atopic dermatitis research and her research identified a novel T-cell subset in humans, T22, that hold a potential therapeutic promise for this disease. For this discovery, and the promise it holds for advancing treatments for atopic eczema, a disease affecting many patients worldwide, Dr. Guttman received the Young Investigator Award of the American Academy of Dermatology.

The ideal candidate for the position will have a strong background in immunology, as well as an interest in dermatology, and atopic dermatitis/eczema in particular, and want to participate in this exciting time with the potential of revolutionizing the known pathways and treatments for this disease. Experience in flow cytometry, tissue culture, molecular biology and immunohistochemistry preferred. Strong publications from Ph.D. are highly preferred.

Applications will be accepted until the position is filled. The position is available immediately.

To apply, please submit the following items to Dr. Emma Guttman at: eguttman@rockefeller.edu

Rockefeller University is an Affirmative Action/Equal Opportunity/VEVRAA Employer and solicits applications from women and under-represented minorities.

Postdoctoral Position in the Mechanisms of pre-mRNA Splicing

We are looking for an individual with a strong interest in mechanistic studies of macromolecular complexes, RNP structure and function, and nucleic acid-protein interactions. The project concerns characterization of exon sequence motifs that act as yeast splicing enhancers by affecting substrate interactions with the spliceosome and altering catalytic steps.

The ideal candidate would have experience working with yeast or with RNA/protein complexes and a strong background in biochemistry, molecular biology, or genetics. The desire to think and design experiments independently is also required. Please send a CV and statement of research interest to:

Magda.Konarska@rockefeller.edu

with: postdoc_Your Name in the subject line.

Rockefeller University is an Affirmative Action/Equal Opportunity/VEVRAA Employer and solicits applications from women and under-represented minorities.

Research Associate/Bioinformatician in Chromatin Analyses

Seeking skilled Ph.D. with expertise in computer analyses of ChIP-seq and microarray data interested in working with a research team conducting molecular biology on epithelial stem cells. Must be trained in computer programming and handling large data sets.

Please send curriculum vitae and statement of research interest to fuchslb@rockefeller.edu.

The Rockefeller University is an Affirmative Action/Equal Opportunity/VEVRAA Employer and solicits applications from women and under-represented minorities.

Postdoctoral Scientist in Biomimetic Nanopores

Nanopores provide new possibilities for the purification and characterization of macromolecules with profound implications for biology, medicine, pharmacology and biotechnology. The nuclear pore complex is a cellular nanopore which has unique abilities for specifically sorting native macromolecules and their complexes at high speed. In an interdisciplinary project involving biochemists, biophysicists and engineers we have created functionalized artificial nanopores mimicking transport properties of the nuclear pore complex (Nature 457 (2009) 1023). We are looking for a postdoctoral scientist who is interested in pursuing the project by applying a whole range of techniques, in particular protein expression and purification, creation of functionalized nanopores, high-resolution light microscopy, innovative flux measurement techniques and the engineering of nanopore-based protein purification machines.

Position available immediately

Interested scientists should send a CV and three references to Beth Anne Hatton (hattonb@mail.rockefeller.edu), Administrative Assistant to Professors Michael Rout, Brian Chait and Reiner Peters.

The Rockefeller University is an Affirmative Action/Equal Opportunity/VEVRAA Employer and solicits applications from women and under-represented minorities.

Rockefeller University NIH CTSA KL2 Clinical Scholars Program
Post Fellowship Patient-Oriented Research Training for Physician-Scientists

The CTSA-supported KL2 Clinical Scholars Program is a three-year Master's degree program with fully protected time designed to provide an optimal environment for physician-scientists starting a career in patient-oriented research. It combines focused research on a project involving human subjects under the direction of a senior Rockefeller University mentor with a comprehensive tutorial-based curriculum in patient-oriented research led by Dr. Barry Coller, Physician-in-Chief. See http://www.rockefeller.edu/ccts/training/KL2program for details. Salary and benefits are competitive.

Please apply on-line at http://scholarapplication.rockefeller.edu/. For additional information contact Dr. Barry Coller; Laboratory of Blood and Vascular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065.

Rockefeller University is an Affirmative Action/Equal Opportunity/VEVRAA Employer and solicits applications from women and under-represented minorities.

The Rockefeller University is an Equal Opportunity Employer with a policy that forbids discrimination in employment (which includes hiring, terms and conditions, promotion, and termination) on the basis of race, color, religion, sex, age, national origin, citizenship status, marital status, sexual orientation, military status, veteran status, or disability. The Administration has an Affirmative Action Program to increase the employment of women and members of protected classes in all areas of the University's activities.