Not Just Another Macrophage
How Ralph Steinman’s controversial discovery of the dendritic cell slowly transformed immunology
DECEMBER 27, 2011
10:30 A.M. – 2:30 P.M.
Lunch served 12 – 1 p.m.
The Rockefeller University
1230 York Avenue
(at E. 66th St)
New York, NY 10065
Lecture by Marina Caskey, Assistant Professor of Clinical Investigation, and Sarah Schlesinger, Associate Professor of Clinical Investigation
Marina Caskey and Sarah Schlesinger, both members of Nobel Prize winner Ralph Steinman's Laboratory of Cellular Physiology and Immunology, are clinicians and immunologists. Dr. Caskey, originally from Brazil, joined Rockefeller upon the completion of her medical residency in 2006. Her research is focused on the development and clinical testing of HIV vaccines and vaccine adjuvants. Dr. Schlesinger, who first came to work with Dr. Steinman as a high school student, has been his collaborator since the early 1990s. She has held positions at the Walter Reed Army Institute of Research and the International AIDS Vaccine Initiative, and joined Rockefeller in 2002. Dr. Schlesinger's research is focused on the clinical manipulation of dendritic cells to elicit immunity to diseases including HIV and cancer.
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Some scientific advances are made in a single moment, their importance and brilliance instantly recognizable. Ralph Steinman’s discovery of the dendritic cell was not one of these.
When Dr. Steinman first described and photographed a new kind of immune cell in 1972 the response from the field was deafening silence. Surely, his colleagues thought, a cell this important to the body’s immune system would already be known; it must just be a new type of macrophage.
For nearly fifteen years, Dr. Steinman and his colleague, Zanvil Cohn, toiled away in relative isolation, working to understand more about the long-armed dendritic cells, which use their characteristic appendages to gather information about invading bacteria and viruses and present it — in the form of antigens — to immune system T cells that launch attacks. Dendritic cells eventually came to be recognized as a critical component of the immune system, without which the body would be able neither to fight infection nor to tolerate its own cells.
Ultimately, with persistence, Dr. Steinman won not only the respect of his field, but also their commendation. This fall, 38 years after his landmark publication, Dr. Steinman was recognized with science’s most prestigious prize, the Nobel. Although it came three days too late for Dr. Steinman himself to enjoy — he died September 30 after a four-year battle with pancreatic cancer — the honor is nevertheless a vindication of Dr. Steinman’s rigor and tenacity. It’s also a reflection of the great promise dendritic cells hold in medicine.
In recent years, Dr. Steinman devoted much of his efforts to pursuing clinical therapies built on dendritic cells. Sarah Schlesinger and Marina Caskey direct clinical trials designed to better understand the role of dendritic cells in the immune systems of healthy human volunteers and the impact of dendritic cellbased vaccines in patients with certain types of disease, including HIV, autoimmune diseases and cancer. In their work, they are picking up where Dr. Steinman left off, translating his fundamental discovery into a new generation of medicine.
of a dendritic cell
2011 Nobel Prize winner
Additional Reading About Dendritic Cells
- Dendritic cells at Rockefeller University
- Ralph Steinman’s research profile
- "Immune Responses" game from the Nobel Foundation
- Steinman, R.M. and Cohn, Z.A. Identification of a Novel Cell Type in Peripheral Lymphoid Organs of Mice I: Morphology, Quantitation, Tissue Distribution. Journal of Experimental Medicine 137, 1142–1162 (1973).*
- Steinman, R.M. and Cohn, Z.A. Identification of a Novel Cell Type in Peripheral Lymphoid Organs of Mice II: Functional Properties in Vitro. Journal of Experimental Medicine 139, 380–397 (1973).*
- Steinman, R.M. Decisions About Dendritic Cells: Past, Present and Future. The Annual Review of Immunology 30, 1–22 (2012). *
- Scientific American profile: How Ralph Steinman Raced to Develop a Cancer Vaccine--And Save His Life *
* Not available on the Web due to copyright restrictions; please e-mail Gloria Phipps at firstname.lastname@example.org for a pdf copy.